Effect of Glucocorticoids on Serum Protein

Effect of Glucocorticoids on Serum Total Protein

Authors: Aqsa Mobeen, Amina Zulfiqar, Afia Jari, Amtul Hafeez, Haider Ali, Zain Imtiaz

Abstract

This study evaluates the effect of glucocorticoids on serum total protein levels in control and experimental groups induced by nephrotoxic poison Concanavalin-A. Results showed significant reduction in total protein and globulin levels in dexamethasone treated group, indicating nephro-protective effects.

Introduction

Kidney diseases are increasing worldwide. Nephrotoxicity caused by drugs and toxic agents leads to kidney damage. Glucocorticoids act as anti-inflammatory agents and help reduce cytokine production and oxidative stress.

Methodology

This experimental study was conducted on 12 animals divided into three groups: control, untreated, and treated. Serum protein levels including albumin, globulin, and A/G ratio were measured.

Groups

  • Control Group – Normal saline
  • Untreated Group – Vehicle + Con-A
  • Treated Group – Dexamethasone + Con-A

Results

Group Total Protein Albumin Globulin A/G Ratio
Control 9.17 7.85 1.32 6.31
Untreated 9.38 6.62 2.76 6.38
Treated 11.91 7.71 4.19 1.98

Discussion

Nephrotoxicity damages kidney function through inflammation and oxidative stress. Dexamethasone reduces inflammation and protects kidney tissues.

Conclusion

Dexamethasone significantly reduces total protein and globulin levels and improves A/G ratio, proving its nephro-protective role.

References

  • Patzer L, 2008
  • So A and Thorens B, 2010
  • Trostel JH, 2015
  • Kim SY, 2012